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Autoimmune Haemolytic Anaemia due to Anti‐Phospholipid Antibodies
Author(s) -
Arvieux J.,
Schweizer B.,
Roussel B.,
Colomb M.G.
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00945.x
Subject(s) - antibody , autoantibody , phospholipid , hemolysis , immunology , chemistry , systemic lupus erythematosus , medicine , lupus erythematosus , autoimmune disease , biochemistry , disease , membrane
. The clinical course and laboratory findings of a patient with autoimmune haemolytic anaemia due to anti‐phospholipid antibodies and secondary to a systemic lupus erythematosus‐like syndrome are described. IgG and IgM with anti‐phospholipid activity coexisted in both sera and acid eluates prepared from the patient's red cells, as demonstrated by ELISA using a panel of anionic and neutral phospholipids. The anti‐erythrocyte binding activity of eluted autoantibodies, determined by a radioactive antiglobulin technique, was totally inhibited by absorption with phospholipid micelles. The patient's serum also contained an IgM warm haemolysin detectable with enzyme‐treated cells only, as well as anti‐C, ‐E and ‐S alloantibodies.