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Significance of Human T‐Lymphotropic Virus Type I Indeterminant Serological Findings among Healthy Individuals
Author(s) -
Lipka James J.,
Young Karen K. Y.,
Kwok Shirley Y.,
Reyes Gregory R.,
Sninsky John J.,
Foung Steven K. H.
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00942.x
Subject(s) - serology , virology , medicine , antibody , virus , immunology , polymerase chain reaction , human t lymphotropic virus , blood transfusion , biology , gene , genetics , myelopathy , psychiatry , spinal cord
. Follow‐up studies on 67 blood donors with indeterminant serological findings for human T‐lymphotropic virus (HTLV) type I by standard immunoassays showed no evidence of infection by polymerase chain reaction analysis for HTLV‐I or HTLV‐II nucleic acids or by antibody reactivity to a unique HTLV‐I recombinant envelope protein, MTA‐4. Among HTLV‐I‐ or ‐II‐infected individuals, a history of blood transfusion, past residence in established HTLV‐I endemic areas or some association with intravenous drug use were common. In contrast, 85% of indeterminant cases had none of these risk factors. These observations suggest that healthy individuals with indeterminant serology for HTLV‐I should not require additional studies.