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Antibody Removal Therapy Used Successfully at Delivery of a Pregnant Patient with Glanzmann's Thrombasthenia and Multiple Anti‐Platelet Antibodies
Author(s) -
Ito Kazuhiko,
Yoshida Hisahiro,
Hatoyama Hiroshi,
Matsumoto Hisashi,
Ban Chiaki,
Mori Takahide,
Sugiyama Tateo,
Ishibashi Takafumi,
Okuma Minoru,
Uchino Haruto,
Maruya Etsuko,
Oki Atsuko,
Saji Hiroh,
Hosoi Takemitsu,
Tanoue Kenjiro,
Tomiyama Yoshiaki,
Kurata Yoshiyuki
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00925.x
Subject(s) - thrombasthenia , glanzmann's thrombasthenia , medicine , platelet , antibody , titer , immunology , platelet transfusion , platelet membrane glycoprotein , plateletpheresis , apheresis , gastroenterology , platelet aggregation
. A 31‐year‐old Japanese woman with Glanzmann's thrombasthenia became pregnant voluntarily. She had had transfusions with more than 60 units for severe bleeding. She had multiple antibodies against HLA antigens and platelet glycoprotein Ilb/IIIa. No compatible platelets were available. To prevent serious hemorrhage during her delivery, antibody removal therapy was carried out three times. Large molecules including immunoglobulins were removed from more than 3 liters of plasma each time. After the titer of antiplatelet antibodies had decreased in the patient's blood, antihuman globulin‐lymphocyte cytotoxicity test compatible platelets were transfused. Her bleeding time improved and delivery was induced successfully despite atonic hemorrhage of about 2,000 g of blood. Her infant had no bleeding problems. This patient is the first with Glanzmann's thrombasthenia to receive antibody removal therapy at delivery.