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Development of Non‐Rh Antibodies in Volunteers Stimulated for the Production of Hyperimmune Anti‐D
Author(s) -
Teesdale Phyllis,
Silva Mahes,
Contreras Marcela
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00924.x
Subject(s) - antigen , antibody , stimulation , immunology , immune system , red cell , red blood cell , medicine , isoantibodies , andrology
. At the North London Blood Transfusion Centre, red cells from accredited Rh‐D‐positive donors, matched for all antigens capable of inducing clinically significant antibodies, are used to stimulate immune plasma donors to achieve higher anti‐D levels. Despite such careful matching, antibody to the relatively non‐immunogenic M antigen developed in 3 out of 20 NN donors (15%) stimulated with M‐positive cells. In general, good responders to the Rh antigen D are good responders to other red cell antigens; our report exemplifies the importance of using fully matched accredited red cells for immune stimulation and the need to perform thorough antibody screening after each stimulation.