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Alanine Aminotransferase, Gamma‐Glutamyltransferase, Antibodies to Hepatitis B Core Antigen and Antibodies to Hepatitis C Virus in Blood Donor Screening
Author(s) -
Ebeling F.
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00909.x
Subject(s) - antibody , medicine , virology , alanine aminotransferase , antigen , hepatitis b virus , immunology , hepatitis b , hepatitis c virus , virus , gastroenterology
. Alanine aminotransferase (ALT), γ‐glutamyl‐transferase and hepatitis B core antibodies were evaluated as donor markers in a prospective study of 685 open‐heart surgery patients. Of these three surrogate markers, only an ALT level greater than or equal to 2 SD above the log mean had a significant association with recipient non‐A, non‐B hepatitis (NANBH, p = 0.02). Antibodies to the hepatitis C virus (anti‐HCV) were detected by an enzyme immunoassay in 7 of the 136 units transfused to the 11 NANBH patients and 29 of 3,650 not associated with hepatitis (p < 0.001). Calculated from this subgroup of donors, the anti‐HCV test would have a 15.6% positive predictive value with 0.92% donor loss and thus is superior as a primary screening marker to all the three surrogate tests. The predictive value could be substantially increased by subsequent ALT testing or by the use of a recombinant immunoblot anti‐HCV assay.