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Antibody‐Coated Erythrocytes Induce Secretion of Tumor Necrosis Factor by Human Monocytes: A Mechanism for the Production of Fever by Incompatible Transfusions
Author(s) -
Hoffman Maureane
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00900.x
Subject(s) - tumor necrosis factor alpha , secretion , monocyte , immunology , antibody , immune system , in vivo , interleukin , cytokine , antigen , biology , medicine , endocrinology , microbiology and biotechnology
. The transfusion of incompatible red blood cells (RBC) rapidly results in the development of fever by an unknown mechanism. In this study, the human monocyte secretion of the endogenous pyrogens tumor necrosis factor (TNF) and interleukin‐1 (IL‐1) was measured. Exposure to human RBC sensitized with antibodies to D or Fy a antigens induced the rapid secretion of TNF, but not IL‐1. TNF secretion persisted when monocytes remained in contact with sensitized RBC, but returned to baseline several hours after removal of RBC. Thus, TNF secreted by monocytes may be a mediator of fever during the immune‐mediated destruction of RBC in vivo.