Premium
Platelet Antibody Binding and Spontaneous Aggregation in 21 Lupus Anticoagulant Patients
Author(s) -
Wiener Henry M.,
Vardi Nurit,
Yust Israel
Publication year - 1991
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1991.tb00256.x
Subject(s) - lupus anticoagulant , platelet , antibody , anticoagulant , immunology , medicine , agglutination (biology) , antiphospholipid syndrome , serology , pathogenesis
In order to ascertain the role of the antiphospolipid antibody in the pathogenesis of thrombotic disorders, a study of 21 lupus anticoagulant‐positive patients was done by a number of serologic and functional platelet tests. In immunofluorescent studies, we found that 80% showed a mitochondrial pattern on HEp cells and all patients gave an ubiquitously intense staining of donor platelets. By a microscopic spontaneous aggregation test, all lupus anticoagulant‐positive patients showed accelerated platelet aggregation which was calcium‐independent. The results show that the plasma of lupus anticoagulant‐positive patients contains a platelet‐binding antibody and causes spontaneous agglutination of platelets. These properties may play a role in the thrombogenesis common to the antiphospholipid syndrome.