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Serological Characterization of Murine Monoclonal Antibodies Directed against Acquired B Red Cells
Author(s) -
Janvier D.,
Veaux S.,
Reviron M.,
Guignier F.,
Benbunan M.
Publication year - 1990
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1990.tb05017.x
Subject(s) - epitope , monoclonal antibody , antibody , serology , microbiology and biotechnology , antigen , red cell , biology , chemistry , virology , immunology , medicine
. Balb/c mice were immunized with acquired B red cells. Twelve clones specific for acquired B red cells were obtained from two fusions. A detailed investigation of three clones is reported here. These antibodies appear to be directed to the B‐like epitope since they are inhibited by galactosamine and fail to react after acetylation of red cells. E 231 is an example of a series of antibodies closely specific for acquired B red cells which can be useful in elucidating some AB0 typing problems. E 167 and F 47 showed a cross‐reactivity with A 1 red cells and a synthetic A trisaccharide. No affinity for B antigen could be demonstrated for any of the antibodies.