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Abnormal Beta and Gamma Sialoglycoprotein Associated with the Low‐Frequency Antigen Ls a
Author(s) -
Macdonald E. B.,
Condon J.,
Ford D.,
Fisher B.,
Gems L. M.
Publication year - 1990
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1990.tb05003.x
Subject(s) - beta (programming language) , antigen , medicine , physics , immunology , computer science , programming language
. This paper describes the association of the low‐frequency antigen Ls a with high‐molecular‐weight variants of β‐ and γ‐sialoglycoproteins (β‐SGP, γ‐SGP). The variant β‐SGP, designated β TL a , carries the Ge 3 epitope and the epitopes recognised by 3 murine monoclonal anti‐β‐SGP antibodies. The variant γ‐SGP, designated γ Ls a , carries the Ge 2 and Ge 3 epitopes. Both β Ls a and γ Ls a showed enhanced reactions in immunoblotting with anti‐Ge 3 sera — which may indicate the presence of 2 Ge 3 epitopes on (β Ls a and γ Ls a . These findings would be consistent with the proposed structure of the Ls a glycophorin C gene.