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A Low‐Incidence Red Cell Antigen JAL Associated with Two Unusual Rh Gene Complexes
Author(s) -
Lomas C.,
Poole J.,
Salaru N.,
Redman M.,
Kirkley K.,
Moulds M.,
McCreary J.,
Nicholson G.S.,
Hustinx H.,
Green C.
Publication year - 1990
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1990.tb02112.x
Subject(s) - antigen , incidence (geometry) , immunology , locus (genetics) , antibody , red cell , gene , biology , isoantibodies , red blood cell , rh blood group system , medicine , genetics , physics , optics
. A multilaboratory investigation during several years has identified a low incidence antigen JAL on the red cells of 7 propositi. JAL appears to be associated with two unusual Rh complexes, one of which produces a depressed C antigen and the other a depressed c antigen. Family studies strongly suggest that the JAL antigen is encoded by the RH locus. Anti‐JAL has been implicated in haemolytic disease of the newborn and is thus considered to be a clinically significant antibody.