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Anti‐Rh(D) IgG Subclasses and Severity of Rh Hemolytic Disease of the Newborn
Author(s) -
Pollock Janet M.,
Bowman John M.
Publication year - 1990
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1990.tb00854.x
Subject(s) - hemolytic disease of the newborn (abo) , gestation , medicine , antibody , immunology , rh blood group system , hemolytic anemia , disease , immunoglobulin g , pregnancy , fetus , biology , genetics
. The influence of anti‐Rh(D) IgG subclasses on the severity of hemolytic disease of the newborn was examined in 98 pregnancies. Disease was severe in 19 of 32 cases in which only IgG1 was detected, 40 of 63 cases in which IgG1 and IgG3 were found and 0 of 3 cases in which only IgG3 was detected. When both IgG1 and IgG3 anti‐D were present, hemolytic disease was more severe than when IgG1 alone was detected. The earliest onset of hydrops was at 20 weeks gestation in the IgG1+IgG3 anti‐Rh group, and at 27 weeks gestation in the IgG1 group.