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A New, Low‐Incidence Red Cell Antigen (HOFM), Associated with Depressed C Antigen
Author(s) -
Hoffmann J.J.M.L.,
Overbeeke M.A.M.,
Kaita H.,
Loomans A.A.H.
Publication year - 1990
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1990.tb00245.x
Subject(s) - antigen , immunology , incidence (geometry) , red cell , medicine , physics , optics
A case of mild hemolytic disease of the newborn is presented which was caused by an antibody to a hitherto unknown antigen of low incidence. This antigen, now designated as HOFM (ISBT number 700050) was detected in 6 relatives, and in all of them, it was associated with an unusually weakened expression of C antigen. The serological data indicate that HOFM may be part of the Rh system, but the genetic data, although supportive of this interpretation, are inconclusive.