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Immune Hemolytic Anemia Associated with Biclonal Cold Autoagglutinins
Author(s) -
Tschirhart Donald L.,
Kunkel Lori,
Shulman Ira A.
Publication year - 1990
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1990.tb00241.x
Subject(s) - autoimmune hemolytic anemia , medicine , autoantibody , antibody , immunology
A 65‐year‐old man with bladder outlet obstruction due to prostatic hypertrophy was incidentally discovered to have cold‐antibody autoimmune hemolytic anemia (cold‐aggluthinin syndrome; CAS) due to autoanti‐I (titer 1,024 at 4°C and 64 at 30°C), and a biclonal gammopathy. Immunofixation electrophoresis of serum and a red blood cell eluate revealed the patient's autoantibody to be biclonal IgMx and IgAx. No underlying cause could be determined to explain the development of either the biclonal gammopathy or the CAS. To our knowledge, this is the first reported case of CAS associated with a biclonal gammopathy and biclonal cold autoagglutinins of the IgMx, IgAx type.