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Additive Solution for the Suspension and Storage of Deglycerolized Red Blood Cells
Author(s) -
Ross D.G.,
Heaton W.A.L.,
Holme S.
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb04953.x
Subject(s) - hemolysis , blood preservation , saline , adenosine triphosphate , chemistry , red cell , red blood cell , in vitro , andrology , medicine , food science , biochemistry , immunology , anesthesia
. The additive solution, ADSOL, was evaluated for its suitability in the extended storage of previously frozen, deglycerolized red blood cells. In vitro comparison with red cells suspended in 0.2% dextrose 0.9% saline showed that ADSOL allowed for significantly enhanced adenosine triphosphate preservation throughout the storage period (>2.2 μmol/g Hb beyond 14 days) and for significantly reduced hemolysis (<1% beyond 14 days). After 10 days of storage in ADSOL the mean recovery after transfusion was 90% (index of therapeutic effectiveness, 77%). No bacterial contamination was observed. The results suggest that this currently approved additive solution could be used to store red cells for 14 days following thawing, thus avoiding one of the principal drawbacks of frozen red cells.