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Effect of Donation Time on Platelet Concentrates and Fresh‐Frozen Plasma. An in vitro Study
Author(s) -
Huh Yang O.,
Lichtiger Benjamin,
Giacco Geoffrey G.,
Guinee Vincent F.,
Drewinko Benjamin
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb03041.x
Subject(s) - platelet , donation , fresh frozen plasma , chemistry , blood donor , whole blood , medicine , immunology , economics , economic growth
. To investigate the effect of donation time on the quality of blood components, we measured the platelet count and pH on platelet concentrates, and the factor V and VIII: C levels and fibrinopeptide A concentration on fresh‐frozen plasma by duration of donation time. Platelet concentrates and fresh‐frozen plasma were classified into three groups according to donation time: group 1, less than 10 min; group 2, 10–15 min, and group 3, longer than 15 min. Mean platelet counts of platelet concentrate were: group 1, 8.6±2.5 (in x 10 10 ), group 2, 8.1±2.6, and group 3, 6.5±3.2 (p<0.05). The same pH was maintained in all three groups. The fibrinopeptide A concentrations in groups 1 and 2 were 24±53 and 169±64 ng/ml, respectively, while in group 3 all were >200 ng/ml, indicating correlation of a higher fibrinopeptide A level with longer donation time. Although a higher fibrinopeptide A level indicated a greater degree of thrombin generation, assays of factors V and VIII: C did not show decreased activity in groups 2 and 3.