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A New HLA‐B Antigen, BHT: Definition by Serological and Biochemical Means
Author(s) -
HajekRosenmayr Agathe,
Jungl Lisi,
Kirnbauer Mia,
Gruber Gerhard,
Mayr Wolfgang R.
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb02042.x
Subject(s) - human leukocyte antigen , antigen , serology , haplotype , locus (genetics) , biology , histocompatibility , microbiology and biotechnology , chemistry , immunology , genetics , antibody , allele , gene
. In 3 unrelated individuals, a new, so far unknown HLA‐B‐locus antigen was found. This HLA‐B antigen, provisionally termed ‘BHT’, is recognized by extra reactions with alloantisera against the B5 cross‐reactive group. BHT can be clearly discerned from all cross‐reactive antigens by one‐dimensional isoelectro focusing (1D IEF), as it reveals, on IEF gels, a characteristic, rather neutral double‐banding pattern different from all known HLA class I bands. The BHT banding pattern, which is identical in all 3 BHT‐positive individuals, segregates with the haplotype A28, BHT, Cw7, DRw6.