Analysis of Natural Killer Cells in Patients with Idiopathic Autoimmune Hemolytic Anemia | Zendy

Conte Roberto | Zendy; Dinota Angelo | Zendy; Tazzari Pier Luigi | Zendy; Belletti Daniela | Zendy; Sermasi Giorgio | Zendy

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Analysis of Natural Killer Cells in Patients with Idiopathic Autoimmune Hemolytic Anemia

Author(s) -

Conte Roberto,

Dinota Angelo,

Tazzari Pier Luigi,

Belletti Daniela,

Sermasi Giorgio

Publication year - 1989

Publication title -

vox sanguinis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.68

H-Index - 83

eISSN - 1423-0410

pISSN - 0042-9007

DOI - 10.1111/j.1423-0410.1989.tb02040.x

Subject(s) - immunology , autoimmune hemolytic anemia , sickle cell anemia , hemolytic anemia , clone (java method) , antigen , population , medicine , cd16 , anemia , natural killer cell , biology , in vitro , cytotoxic t cell , antibody , disease , gene , biochemistry , environmental health , cd3 , cd8

. A functional and phenotypic analysis of the circulating natural killer (NK) cell population was carried out in 9 patients with idiopathic autoimmune hemolytic anemia (IAHA). The NK‐cell activity, assessed by a sensitive method based on the inhibition of target clone growth in plasma semisolid medium, was markedly decreased in all patients as compared with normal controls and was not restored by stimulation of the cells with recombinant α interferon (α‐IFN). Analysis of peripheral blood phenotypic markers showed that cells bearing Leu7 and CD16 antigens numbered in the normal range. These findings suggest that IAHA patients exhibit a functional impairment of the NK compartment.

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