Premium
Use of a High‐Purity Factor VIII Concentrate (Hemate P) in von Willebrand's Disease 1
Author(s) -
Berntorp Erik,
Nilsson Inga Marie
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb02031.x
Subject(s) - von willebrand disease , von willebrand factor , hemostasis , medicine , coagulopathy , disease , blood product , gastroenterology , surgery , platelet
. In previous studies, we have found Hemate P (Behring) to be the only commercial virus‐inactivated high‐purity factor VIII concentrate that contains native von Willebrand factor. In the present study, Hemate P was given to 7 patients with the severe recessive form of von Willebrand's disease, to 2 patients with type Ia, to 1 patient with type IIB, and to 1 patient with type IIC von Willebrand's disease. A correction of the hemostatic defect was seen in all patients. Satisfactory hemostasis was also obtained in clinical situations, 1 patient undergoing major surgery and another being delivered, both without undue loss of blood. We conclude that Hemate P is an efficacious and safe product for use in cases of von Willebrand's disease when pharmacological correction of the hemostatic defect is not possible.