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A New Platelet‐Specific Antigen, Nak a , Involved in the Refractoriness of HLA‐Matched Platelet Transfusion
Author(s) -
Ikeda Hisami,
Mitani Takako,
Ohnuma Miki,
Haga Hiroshi,
Ohtzuka Sayuri,
Kato Toshiaki,
Nakase Toshie,
Sekiguchi Sadayoshi
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb00826.x
Subject(s) - nak , platelet , antigen , epitope , antibody , immunology , monoclonal antibody , immunofluorescence , human leukocyte antigen , population , microbiology and biotechnology , biology , medicine , computer network , telecommunications link , environmental health , computer science
Abstract. Serum from a thrombocytopenic patient who was refractory to the transfusions of HLA‐matched platelets contained a platelet‐specific alloantibody, anti‐Nak a . Immunofluorescence analyses revealed that the Nak a antigen defined by the serum was expressed exclusively on platelets and its distribution was different from Pl A1 , Bak a , Yuk a or Yuk b . Analysis by Dr. von dem Borne's group revealed the Nak a was also different from Ko a , Ko b or Zw b . Family studies showed that the Nak a antigen was inherited as an autosomal codominant trait. Its antigen frequency in the Japanese population was over 97%. The results of the enzyme immunoassay using monoclonal antibodies for antigen immobilization showed that the Nak a epitope did not appear to reside on GPIIb/IIIa or Ib. The transfusions of Nak a ‐compatible platelets improved the patient's thrombocytopenia.