Premium
Platelet Anti‐BAK b Antibody Associated with Neonatal Alloimmune Thrombocytopenia
Author(s) -
McGrath K.,
Minchinton R.,
Cunningham I.,
Ayberk H.
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb00819.x
Subject(s) - platelet , antibody , antiserum , neonatal alloimmune thrombocytopenia , antigen , isoantibodies , immunology , immunofluorescence , immunoprecipitation , medicine , microbiology and biotechnology , biology , pregnancy , genetics , fetus
. A platelet alloantibody of IgG class but unknown specificity was detected in the serum from the mother of an infant with neonatal alloimmune thrombocytopenia. The antibody reacted by indirect immunofluorescence with 33/65 random donors, 10/11 Bak a ‐negative donors and 23/54 Bak a ‐positive donors. The mother's platelet phenotype was PLA 1 , Ko a , Ko b , Bak a and the father's was PLA 1 , Ko a , Ko b , Bak a . Immunoblotting and immunoprecipitation of maternal serum with paternal platelets produced a band at molecular weight 140 kilodaltons identical to the band obtained with Bak a antiserum. Family studies confirmed the allelic distribution of Bak a and the unknown antigen. The platelet‐specific antibody in this patient meets the criteria for an antibody to the new platelet antigen, Bak b .