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Leukocyte‐Poor Platelet Concentrates at the Bedside by Filtration through Sepacell‐PL
Author(s) -
Miyamoto Masaki,
Sasakawa Shigeru,
Ishikawa Yoshihide,
Ogawa Atsuko,
Nishimura Takao,
Kuroda Toru
Publication year - 1989
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1989.tb00815.x
Subject(s) - platelet , filtration (mathematics) , chromatography , chemistry , filter (signal processing) , saline , biomedical engineering , medicine , immunology , anesthesia , mathematics , computer science , statistics , computer vision
. We developed a new filter, ‘Sepacell‐PL’, consisting of a blood administraiton set for the preparation of leukocyte‐poor platelet concentrates at the patient's bedside. This filter is packed with 1.8 μm polyester fibers coated with a new polymer, and has a volume of 14 ml. Sepacell‐PL removed more than 99% of the leukocytes while approximately 93% of platelets were recovered from 10 units of platelet concentrates which contained 5 times 10 8 leukocytes and 3 times 10 11 platelets. The functions of pre‐ and postfiltrated platelets were unchanged. The filtration procedure is very simple, without priming with saline to remove air and wet the filter. Moreover, platelet concentrates can be passed through the filter at a flow rate of 4 ml/min, or at a higher flow rate of 54 ml/min by gravity.