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Evidence for the Occurrence of Human Erythrocyte Membrane Sialoglycoproteins in Human Kidney Endothelial Cells
Author(s) -
Harvey J.,
Parsons S.F.,
Anstee D.J.,
Bradley B.A.
Publication year - 1988
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1988.tb05144.x
Subject(s) - sialoglycoproteins , epitope , glycophorin , monoclonal antibody , endothelium , antibody , sialidase , biology , human kidney , kidney , neuraminidase , sialic acid , immunology , biochemistry , endocrinology , antigen , virus
. Several mouse monoclonal antibodies recognising different epitopes on human erythrocyte sialoglycoproteins a and β (syn: glycophorins A and C, respectively) react with human renal endothelium. Those monoclonal anti‐blood group M and anti‐blood group N antibodies which recognised the M/N epitopes on sialidase‐treated human erythrocytes also reacted with human renal endothelium whilst those which recognise the M/N epitopes on native, but not on sialidase‐treated human erythrocytes were not reactive with human renal endothelium. These results provide evidence for the occurrence of α and β molecules in renal endothelium and suggest that α in renal endothelium is incompletely sialylated.