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Coexisting Anti‐I and Anti‐Fl/Gd Cold Agglutinins in Infections by Mycoplasma pneumoniae
Author(s) -
König A.L.,
Kreft H.,
Hengge U.,
Braun R. W.,
Roelcke D.
Publication year - 1988
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1988.tb05088.x
Subject(s) - cold agglutinin , mycoplasma pneumoniae , antibody , microbiology and biotechnology , antigen , sialic acid , atypical pneumonia , mycoplasma , mycoplasma pneumonia , pneumonia , immunology , serology , virology , biology , medicine , biochemistry
. 192 sera containing cold agglutinins of apparent anti‐I specificity were reinvestigated for concomitant cold agglutinins (CA) against sialic acid‐dependent antigens. 35 cases of additional anti‐Fl and 3 cases of additional anti‐Gd were detected. 53% of cases with coexisting anti‐I and anti‐Fl/Gd CA had a clinical diagnosis of pneumonia, in 39% IgM antibodies against Mycoplasma pneumoniae could be demonstrated. Since Fl and Gd antigens are identical with the structures identified as receptors for M.pneumoniae , the findings support the hypothesis that postinfectious CA are directed against the receptor of the infectious agent.