Premium
Preparation of Leucocyte‐Poor Platelet Concentrates from Buffy Coats
Author(s) -
Pietersz R.N.I.,
Reesink H. W.,
Huijgens P.C.,
Oers M.H.J.
Publication year - 1988
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1988.tb05078.x
Subject(s) - platelet , medicine , buffy coat , platelet transfusion , blood transfusion , surgery , gastroenterology
. To study survival and function of leukocyte‐poor platelet concentrates (lp‐PC) prepared from buffy coats, random platelet transfusions requested for thrombocytopenic patients were evaluated. The lp‐PC issued were stored at 22°C for either 1, 3 or 5 days before transfusion. From 31 transfusions, posttransfusion corrected count increments (CCI), corrected for body surface (m 2 ) and divided by number of platelets transfused (10 11 ), were calculated. The mean ±SEM of the 1‐, 24‐and 48‐hour CCI was 12.2 ± 0.45, 11.2 ± 0.51 and 8.8 ± 0.58, respectively. No significant differences in CCI 24 h after transfusion were observed for lp‐PC stored for 1, 3 or 5 days. Hemostatic activity was observed in all 9 evaluable patients. It is concluded that platelets from lp‐PC survive well in patients, regardless of storage for 1, 3 or 5 days and that the platelets are hemostatically active after transfusion.