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Erythromycin‐Induced Immune Hemolytic Anemia
Author(s) -
Nance Sandra J.,
Ladisch Stephan,
Williamson Timothy L.,
Garratty George
Publication year - 1988
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1988.tb04703.x
Subject(s) - erythromycin , hemolytic anemia , medicine , immune system , anemia , immunology , antibiotics , microbiology and biotechnology , biology
. A 3‐year‐old female receiving Pediazole (erythromycin ethylsuccinate and sulfisoxazole) for tonsillitis and otitis media developed severe hemolytic anemia. No serum drug‐dependent antibodies could be demonstrated with an in vitro ‘immune‐complex’ method using Pediazole, pure erythromycin ethylsuccinate or pure sulfisoxazole. However, a method using red cells coated with erythromycin base showed in vitro lysis of the erythromycin‐coated red cells. This is only the second case of immune hemolytic anemia associated with erythromycin and the first where in vitro drug‐dependent hemolysis was demonstrable.