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Transfusion Significance of LW a Allo‐Antibodies
Author(s) -
Napier J.A.F.,
Rowe G.P.
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb05071.x
Subject(s) - antibody , in vivo , immunization , in vitro , immunology , medicine , cytotoxicity , macrophage , complication , chemistry , biology , biochemistry , genetics
. An example of anti‐LW a , arising as a complication during a RhD immunization programme, has been studied for evidence of its likely in vivo haemolytic properties. In vitro testing of the anti‐LW a showed it to be largely IgG1 acting by the antiglobulin technique. Results of antibody‐dependent cellular cytotoxicity and macrophage phagocytic assays were both negative. However, 99m Tc‐labelled Lw(a+) donor cells showed a slight reduction in t 1/2> (18 h) compared with the normal survival of autologous cells. Despite this observation, and bearing in mind the difficulties of interpreting apparently accelerated destruction of small volumes of serologically incompatible red cells, it was concluded that the presence of this example of anti‐LW a should not be a bar to urgent transfusion.