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Survival of Red Cells Stored for 21 and 35 Days in a Non‐Di‐(2‐Ethylhexyl)Phthalate Plastic Container
Author(s) -
Myhre Byron A.,
Johnson Delores,
Marcus Carol S.,
Demaniew Suzanne,
Carmen Raleigh,
Nelson Ed
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb05066.x
Subject(s) - phthalate , plasticizer , blood preservation , andrology , chemistry , phosphate buffered saline , food science , chromatography , medicine , organic chemistry
. Whole blood and red cells were stored using citrate‐phosphate‐dextrose (CPD) and citrate‐phosphate‐dextrose‐adenine (CPDA‐1) anticoagulants in polyvinylchloride bags made flexible with di‐(2‐ethylhexyl)phthalate (DEHP) or tri‐(2‐ethylhexyl)trimellitate (TOTM) plasticizers. After storage the posttransfusion viability of these cells was tested in autologous donors. Cells stored in TOTM‐plasticized film had a survival rate less than 75% when stored for 35 days, while other systems had a survival greater than this. When compared with the red cells stored in CPD‐DEHP‐plasticized film, the viability of whole blood and red cells stored in CPDA‐TOTM showed a statistically significant decrease ( p = <0.01). Therefore, red cell storage in TOTM‐plasticized PVC with current anticoagulant should be limited to 21 days.