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Effects of Plasticizers and Plastic Bags on Granulocyte Function during Storage
Author(s) -
Miyamoto Masaki,
Sasakawa Shigeru
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb04907.x
Subject(s) - plasticizer , polyvinyl chloride , phthalate , plastic bag , granulocyte , chemistry , vinyl chloride , food science , chromatography , waste management , medicine , immunology , organic chemistry , polymer , copolymer , engineering
. The influence of the plasticizers, di‐(2‐ethylhexyl)phthalate (DEHP) and tri‐(2‐ethylhexyl)trimellitate (TOTM), on granulocyte function was examined. Polyvinyl chloride (PVC) bags with DEHP (DEHP‐PVC) leaked DEHP into plasma, but TOTM did not dissolve in plasma under the same conditions. Glow discharge treatment inhibited the leakage of DEHP from DEHP‐PVC bags. Depending on the amount of DEHP added into granulocyte suspension, chemotaxis and bactericidal activity decreased, but cell counts and phagocytosis were not affected. During storage for 24 h at 22 °C, granulocyte function decreased greatly in DEHP‐PVC, but was well maintained in the bags which did not leak plasticizers, TOTM‐PVC and glow‐discharged DEHP‐PVC.