Premium
Post‐Transfusion Purpura Associated with Anti‐Bak a and Anti‐Pl A2 Platelet Antibodies and Delayed Haemolytic Transfusion Reaction
Author(s) -
Chapman J.F.,
Murphy M.F.,
Berney S.I.,
Ord J.,
Metcalfe P.,
Amess J.A.L.,
Waters A.H.
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb04899.x
Subject(s) - platelet , antibody , medicine , immunology , purpura (gastropod) , blood transfusion , transfusion reaction , platelet transfusion , red cell , red blood cell , biology , ecology
. The occurrence of post‐transfusion purpura (PTP) in a 16‐year‐old girl with sickle/β‐thalassaemia is described. Clinically this was a typical case of PTP, but it was unusual serologically. Anti‐Bak a and anti‐Pl A2 platelet‐specific antibodies were identified and the patient's platelets were typed as homozygous Pl A1 ‐positive and Bak a ‐negative. The patient also developed red‐cell, granulocyte and lymphocytotoxic antibodies in response to the blood transfusion and had a delayed haemolytic transfusion reaction.