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MER2: A Red Cell Polymorphism Defined by Monoclonal Antibodies 1
Author(s) -
Daniels G.L.,
Tippett P.,
Palmer D.K.,
Miller Y.E.,
Geyer D.,
Jones C.
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb03002.x
Subject(s) - monoclonal antibody , microbiology and biotechnology , biology , somatic cell , red blood cell , antibody , genetics , mendelian inheritance , gene , antigen , monoclonal , polymorphism (computer science) , red cell , immunology , genotype , medicine
. Two murine monoclonal antibodies, ID12 and 2F7, apparently of the same specificity, define a new red cell polymorphism, MER2. 92% of English blood donors are MER2+ giving the gene frequencies MER2 + 0.7159; MER2 ‐ 0.2841. Family studies showed that MER2 + is inherited as a Mendelian dominant character and that MER2 is not controlled by any of the main blood group loci. The MER2 antigen is also present on some leukaemia fibroblasts and human cell lines. Using somatic cell hybrids, MER2 appears to be coded for by a gene on chromosome 11 at 11p15.