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Comparison of Monoclonal Antisera with Conventional Antisera for Lewis Blood Group Antigen Determination
Author(s) -
Cowles J.W.,
Cox M.T.,
McMican A.,
Blumberg N.
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb02996.x
Subject(s) - polyclonal antibodies , antiserum , monoclonal antibody , monoclonal , reagent , antigen , blood group antigens , microbiology and biotechnology , chemistry , biology , immunology , antibody
. Monoclonal blood grouping sera provide a means of overcoming difficulties inherent in the use of conventional polyclonal reagents. Two murine monoclonal anti‐Lewis reagents were tested and found to be comparable to conventional reagents for use in red cell phenotyping. These reagents may detect Le a antigen on Le(a–b+) red cells with greater sensitivity than previously available polyclonal anti‐Lewis reagents.