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Serological Characterisation of a Mouse Monoclonal Anti‐P‐Like Antibody
Author(s) -
Inglis G.,
Fraser R.H.,
Mitchell A.A.B.,
Mackie A.,
Allan E.K.,
Mitchell R.
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb02995.x
Subject(s) - immunogen , monoclonal antibody , epitope , antibody , serology , escherichia coli , galactosamine , microbiology and biotechnology , monoclonal , biology , chemistry , virology , immunology , biochemistry , galactose , gene
. An IgM mouse monoclonal antibody, LM 147/328, raised against an Escherichia coli immunogen, was found to possess anti‐P‐like specificity. It is proposed that this antibody recognises an epitope on a Galβ1–3GalNAc disaccharide structure (GalNAc = N‐acetyl‐ D ‐galactosamine). The haemagglutinating activity of this antibody was consistently strong with adult erythrocytes, but gave significantly weak reactions with about 7% of cord erythrocyte samples.