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Effects of Storage on the Pyruvate‐Lactate System and Random Migration of Human Granulocytes
Author(s) -
Paul J.L.,
Abbouyi A. El,
RochArveiller M.,
Giroud J. P.,
Agneray J.,
Yonger J.,
Raichvarg D.
Publication year - 1987
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1987.tb02983.x
Subject(s) - lysis , intracellular , granulocyte , function (biology) , chemistry , chemiluminescence , biochemistry , neutrophile , biology , immunology , microbiology and biotechnology , in vitro , chromatography
. This work demonstrates a time‐dependent loss of polymorphonuclear neutrophilic leukocyte (PMN) functions during the first 48 h with only slight lysis and release of cellular LDH. It confirms that storage decreases ATP levels in PMNs and significantly increases intracellular lactate and pyruvate. These data correlated with an inhibition of PMN migratory function and a considerable decrease in chemiluminescence response.