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Acquired Loss of Red‐Cell Wj Antigen in a Patient with Hodgkin's Disease
Author(s) -
Mannessier Lucienne,
Rouger Phillipe,
Johnson Carol L.,
Mueller Kathleen A.,
Marsh W. Laurence
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb04889.x
Subject(s) - disease , medicine , antigen , immunology , red cell , intensive care medicine
. A patient with Hodgkin's disease became temporarily Wj‐negative with alloanti‐Wj in his serum. Four human autoantibodies, and 1 of 2 murine monoclonal antibodies, with serological characteristics of anti‐Wj were nonreactive with his red cells, confirming that they have anti‐Wj specificity. Six siblings of the patient are all Wj‐positive. The patient was also temporarily Anton‐negative, and cross‐testing between Wj and Anton red cells and antisera showed mutual compatibility, indicating that the antigens are the same. The patient and 3 of his 6 siblings are also of the rare Lu: ‐13 phenotype, providing the first evidence that this is an inherited characteristic.