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A Rare Blood Group Antigen, Ol a (Oldeide), Associated with Weak Rh Antigens 1
Author(s) -
Kornstad Leif
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb04888.x
Subject(s) - abo blood group system , antigen , antiserum , blood group antigens , rh blood group system , h antigen , biology , immunology , mendelian inheritance , antibody , medicine , gene , genetics
. A ‘new’, rare blood group antigen, Ol a (Oldeide), is described. Only one Ol(a+) person was found among the 7, 151 blood donors tested. Examination of the family of the proposita revealed 10 additional Ol(a+) persons. The study indicated that Ol a is inherited as a Mendelian dominant character and segregates independently of the ABO, MNSs, P, Rh and Kidd blood group systems, of the ABH secretor genes, and of sex. Ol(a+) family members had depressed Rh antigens, while the Ol(a‐) members had Rh antigens of normal strength. The depression was particularly pronounced for the C and E antigens, less marked for the D antigen. Individual antisera differed in their ability to demonstrate the presence of the antigens. Depression of the c and e antigens could not be demonstrated conclusively with the antisera available.