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Heterogeneity of Lewis Antibodies. A Comparison of the Reaction of Human and Animal Reagents with Synthetic Oligosaccharides
Author(s) -
François A.,
Sansonetti N.,
Mollicone R.,
Pendu J. Le,
Galton J.,
Jaulmes B.,
Oriol R.
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb04887.x
Subject(s) - epitope , chemistry , reagent , lewis acids and bases , cross reactions , stereochemistry , antibody , biochemistry , organic chemistry , biology , catalysis , immunology
. Human as well as animal anti‐Lewis reagents were shown to have different binding patterns to synthetic structures chemically related to the Lewis epitopes. Two main types of cross‐reactions were found: (1) Cross‐reactions among type 1 Lewis epitopes (Le a , Le b and Lewis disaccharide). This type of cross‐reaction among different type 1 structures was predominant in anti‐Le a reagents (16 out of 18), although it was also present in some anti‐Le b reagents (4 out of 14). (2) Cross‐reactions of Le a and Le b with their type 2 isomers X and Y. The Le b ‐Y cross‐reaction was more frequent (7 out of 14) than the Le a ‐X cross‐reaction (2 out of 18). The serological property of some anti‐Lewis reagents reacting with cord cells (‘Le x ’) is also shown to be heterogenous although probably related to common features of the type 1 Le a and Le b epitopes and independent of the type 2 X and Y epitopes.