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Efficacy of Performing Red‐Cell Antibody Elutions in Patients with a Positive Direct Antiglobulin Test
Author(s) -
Domen Ronald E.,
Grattan Jean
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb01978.x
Subject(s) - antibody , red cell , medicine , coombs test , immunology , isoantibodies , red blood cell , hemagglutination tests , hemagglutination
. Red blood cell antibody elutions are often routinely performed whenever a positive direct antiglobulin test (DAT) is encountered. To evaluate the efficacy of performing routine red‐cell elutions we reviewed our antibody elution data. Of 122 eluates, 83 were negative, 35 were warm panagglutinins, 2 were felt to be transfusion‐induced alloantibodies, 1 was passively acquired anti‐A, and 1 was inconclusive. One of the eluted alloantibodies was not demonstrable in the serum. Thus, only 1 (0.8%) of the eluates provided important information not readily available through serum testing alone. We conclude that extensive serologic evaluation of a positive DAT should be reserved for those patients who have been recently transfused or are suspected of having immune hemolysis.