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Proposal for the Nomenclature of Human Plasminogen (PLG) Polymorphism
Author(s) -
Skoda Ulrike,
Bertrams J.,
Dykes D.,
Eiberg H.,
Hobart M.,
Hummel K.,
Kühnl P.,
Mauff G.,
Nakamura S.,
Nishimukai H.,
Raum D.,
Tokunaga K.,
Weidinger S.
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb01963.x
Subject(s) - typing , nomenclature , biology , genetics , polymorphism (computer science) , allele , isoelectric focusing , computational biology , gene , taxonomy (biology) , biochemistry , botany , enzyme
. Since its discovery, human plasminogen (PLG) polymorphism has received widespread acceptance in population genetics and forensic haematology. Due to the large number of variant alleles described, a PLG reference typing and Plasminogen Symposium was held, at which a nomenclature proposal was inaugurated. The technology of comparing PLG variants was based on isoelectric focusing and subsequent detection by caseinolytic overlay and ‘Western’ blotting. Typing results permitted comparison of so far described variant designations and resulted in a new nomenclature proposal for PLG polymorphism. It is recommended that the two most common alleles found in all investigated races be called: PLG*A (previously also PLG*1 ) and PLG*B (previously also PLG*2 ), the known variants with acidic pI: PLG*A1 to *A3 , intermediate variants: PLG*M1 to *M5, PLG*M5 being functionally inactive, and basic variants: PLG*B1 to *B3. For future classification of newly discovered variants, samples should be compared at any of the laboratories participating in the reference typing.