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An Infant Girl with Severe Autoimmune Hemolytic Anemia: Apparent Anti‐Vel Specificity 1
Author(s) -
Becton David L.,
Kinney Thomas R.
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb00224.x
Subject(s) - autoimmune hemolytic anemia , medicine , autoantibody , hemolytic anemia , immunology , anemia , malignancy , antibody , autoimmune disease , antigen , red cell
. Autoantibodies directed against the common red‐cell antigen Vel are unusual, with only 2 previous cases reported. This report describes an infant girl with steroid‐resistant autoimmune hemolytic anemia whose serum contained an antibody with apparent specificity for Vel antigen. Transfusion with Vel‐positive cells resulted in a massive hemolytic transfusion reaction. Survival of labelled Vel‐negative cells was normal up to 8 h following transfusion, and no transfusion reaction followed subsequent use of Vel‐negative cells. There was no evidence of a collagen vascular disease, an immunodeficiency syndrome, or a malignancy. Although rare, anti‐Vel should be considered in unexplained autoimmune hemolytic anemia.