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Pulmonary Reaction Associated with Transfusion of Plasma Containing Anti‐5b
Author(s) -
Nordhagen Rannveig,
Conradi Marius,
Drömtorp Signe M.
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb00223.x
Subject(s) - agglutination (biology) , antibody , medicine , respiratory distress , granulocyte , immunology , incubation , fresh frozen plasma , red cell , platelet , chemistry , anesthesia , biochemistry
. A patient developed an acute respiratory distress syndrome with lung infiltrates during a transfusion of plasma. The transfused plasma was shown to contain a potent leucocyte agglutinating antibody of IgG type with anti‐5b specificity, reactive with the patient's cells. A review of the literature on similar transfusion‐related syndromes showed an association with more of less well‐defined white cell antibodies, mainly in the donors' plasma. The majority of donors were multiparous women. The anti‐5b in our donor was demonstrated only by granulocyte agglutination technique, as previously described antibodies in the five system. A long incubation procedure (20–25 h) seemed to be optimal for granulocyte agglutination.