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Correlation of Immune Defects in Hemophilia with HTLV‐III Antibody Titers
Author(s) -
Daniel V.,
Opelz G.,
Schäfer A.,
Schimpf Kl.,
Wendler I.,
Hunsmann G.
Publication year - 1986
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1986.tb00205.x
Subject(s) - titer , neopterin , antibody , immunology , pokeweed mitogen , medicine , immune system , antibody titer , in vitro , biology , peripheral blood mononuclear cell , biochemistry
. Of 170 hemophilia patients, 22% had high‐titer, 29% had low‐titer, and 49% had no antibodies against HTLV‐III. The strength of HTLV‐III antibodies was correlated significantly with a decreased OKT4/T8 ratio (p < 0.0005), decreased in vitro response to pokeweed mitogen (p < 0.025), and elevated serum neopterin (p < 0.05) and serum IgG (p < 0.0005). The fraction of patients with abnormal immunological findings was consistently greater among patients with high‐titer than among patients with low‐titer HTLV‐III antibodies. Testing these immunological parameters may be useful for monitoring the breakdown of immune functions leading to AIDS.