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Antiglycolipid Antibodies in Normal and Pathologic Human Sera and Synovial Fluids
Author(s) -
Kaise Shunji,
Yasuda Tatsuji,
Kasukawa Reiji,
Nishimaki Tomoe,
Watarai Shinobu,
Tsumita Toru
Publication year - 1985
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1985.tb01124.x
Subject(s) - antibody , antigen , ganglioside , titer , immunology , medicine , pathology , microbiology and biotechnology , chemistry , biology , biochemistry
Antiglycolipid antibodies were measured in normal and pathologic sera and synovial fluids by means of a modified microplate method of complement‐mediated immune lysis of fluorescent dye‐trapped liposomes. All sera of normal subjects had antibodies against globopentaosylceramide (IV 3 GalNAcGbOse 4 Cer), ganglioside G MI , gangliotriaosylceramide, gangliotetraosylceramide, and galactosylneolactotetraosylceramide antigens. Most sera of normal subjects had antibodies against lactotriaosylceramide, N‐glycolylneuraminosyl‐neolactotetraosylceramide (NeuGcnLcOse 4 Cer), G M3 ganglioside with N‐glycolylneuraminic acid (NeuGcG M3 ) and G DIa antigens. Differences of titers against IV 3 GalNAcGbOse 4 Cer, neolactotetraosylceramide, NeuGcG M3 and NeuGcnLcOse 4 Cer antigens were observed between sera of normal subjects and pathologic sera from cases of leukemias, lymphomas, several autoimmune diseases and liver diseases.

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