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Deficiency of Autologous Mixed Lymphocyte Reaction in Patients with Idiopathic Autoimmune Hemolytic Anemia
Author(s) -
Conte Roberto,
Tazzari Pier Luigi,
Finelli Carlo
Publication year - 1985
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1985.tb01123.x
Subject(s) - autoimmune hemolytic anemia , immunology , medicine , mixed lymphocyte reaction , hemolytic anemia , lymphocyte , anemia , antibody , immune system , t cell
Alterations in the autologous mixed lymphocyte reaction (autologous MLR) have been reported in many autoimmune diseases and in diseases with a derangement of T regulatory function. We have studied autologous MLR in 10 patients with idiopathic autoimmune hemolytic anemia (IAHA). All patients had decreased autologous MLR which averaged 4,106+1,332 cpm (SEM) compared to 12,153+4,166 cpm for simultaneously studied controls. A marked decrease in phytohemagglutinin response and an imbalance of T‐cell subsets were also observed. These findings suggest a possible abnormality of T immuno‐regulatory function in IAHA patients.