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Phospholipid Dependence of Wr b Antigen Expression in Human Erythrocyte Membranes
Author(s) -
Rearden Ann
Publication year - 1985
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1985.tb00810.x
Subject(s) - glycophorin , phospholipid , monoclonal antibody , red blood cell , membrane , erythrocyte membrane , antigen , antibody , biochemistry , chemistry , microbiology and biotechnology , biology , immunology
Phospholipid depletion of human erythrocyte membranes by phospholipase A 2 modification markedly decreased binding of two monoclonal antibodies to the Wr b (Wright) blood group determinant on glycophorin A. Binding of seven monoclonal antibodies to other glycophorin A determinants, including anti‐M and anti‐N, was unaffected by phospholipid depletion. These results indicate that Wr b antigen expression is phospholipid‐dependent in human erythrocyte membranes.