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Use of Chloroquine‐Treated Granulocytes and Platelets in the Diagnosis of Immune Cytopenias
Author(s) -
Metcalfe P.,
Minchinton R.M.,
Murphy M.F.,
Waters Prof.A.H.
Publication year - 1985
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1985.tb00809.x
Subject(s) - platelet , immunology , medicine , antibody , chloroquine , neutropenia , neonatal alloimmune thrombocytopenia , immune system , platelet transfusion , malaria , pregnancy , biology , chemotherapy , fetus , genetics
A chloroquine modification of the fluorescent antiglobulin technique has been used to demonstrate cell‐specific antibodies in the presence of HLA antibodies. This is of particular value in the diagnosis of alloimmune neonatal thrombocytopenia and neutropenia, post‐transfusion purpura, and in the investigation of febrile non‐haemolytic transfusion reactions and of patients refractory to platelet transfusions.