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Antibodies to HTLV‐III and the Lymphadenopathy Syndrome in Multitransfused β‐Thalassemia Patients
Author(s) -
Martino M.,
Quarta G.,
Melpignano A.,
Guadalupi C.,
Vullo C.,
Ferrucci M.,
Saimot A. G.,
Vierucci A.
Publication year - 1985
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1985.tb00798.x
Subject(s) - medicine , thalassemia , hemoglobinopathy , antibody , beta thalassemia , retrospective cohort study , pediatrics , immunology , dermatology , surgery , disease
. Antibodies to HTLV‐III have been investigated in 118 multitransfused β‐thalassemia patients. Thirteen patients (11.01%) were found to be positive; 3 of these 13 showed clinical and immunological signs of the lymphadenopathy syndrome. A retrospective study carried out on 65 sera has shown that at least 6 patients were negative 3 years before the present investigation. This is the first extensive study on HTLV‐III infection in multitransfused β‐thalassemics. It suggests that these patients are at risk for the acquired immune deficiency syndrome and related diseases.