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Human Monoclonal Antibodies against Group A Red Blood Cells
Author(s) -
Raubitschek Andrew,
Senyk George,
Larrick James,
Lizak Gail,
Foung Steven
Publication year - 1985
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1985.tb00186.x
Subject(s) - monoclonal antibody , antibody , monoclonal , virology , red blood cell , in vitro , microbiology and biotechnology , immunology , biology , group a , chemistry , medicine , biochemistry
. A human monoclonal antibody with anti‐A specificity was generated by Epstein‐Barr virus transformation of lymphocytes isolated from splenic tissue after in vitro stimulation with group A red blood cells. This antibody is of the IgM class and directly agglutinates group A red blood cells. Type A 1 , A 2 , A int , A 3 , A x , A end and A 5 cells were agglutinated by the reagent indicating a single determinant is shared by these A subgroups.