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An Immediate Hemolytic Transfusion Reaction Due to Anti‐C and a Delayed Hemolytic Transfusion Reaction Due to Anti‐Ce+e: Hemoglobinemia, Hemoglobinuria and Transient Impaired Renal Function
Author(s) -
Molthan Lyndall,
Matulewicz Theodore J.,
BansalCarver Bala,
Benz Edward J.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb04138.x
Subject(s) - hemoglobinuria , medicine , antibody , blood transfusion , paroxysmal nocturnal hemoglobinuria , gastroenterology , hemolytic anemia , immunology , hemolysis
. A patient with phenotype R 2 r and anti‐C had a hemolytic transfusion reaction (HTR) with hemoglobinemia and hemoglobinuria which occurred within 2 h of receiving an R 1 r transfusion. Transient impaired renal function ensued. A patient with phenotype R 2 R 2 and anti‐Ce+e had the same experience on day 4 after receiving three R 1 r and one rr units. 2 other patients, 1 R 2 r with anti‐C who received one R 1 r unit and the other R 2 R 2 with anti‐Ce+e who received two R 1 r units, showed no clinical evidence of HTR. Both anti‐C antibodies were entirely IgG while both anti‐Ce+e antibodies initially were predominantly IgM. IgG subclassing was unsuccessful and red blood cell‐mononuclear phagocyte assays were normal. These cases occurred from 1979 to 1981.