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Studies on Low‐Dose Hydroxyethyl Starch Leukapheresis: Rate of Elimination of HES in vivo and Function of the Harvested Granulocytes in vitro 1
Author(s) -
Szymanski Irma O.,
Teno Richard A.,
Gandhi Jitendra G.,
Newburger Peter E.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb04134.x
Subject(s) - leukapheresis , hydroxyethyl starch , in vivo , in vitro , venipuncture , granulocyte , andrology , chemistry , medicine , immunology , biology , anesthesia , biochemistry , genetics , microbiology and biotechnology , stem cell , cd34
. We studied the rate of in vivo elimination of hydroxyethyl starch (HES) given during low dose HES leukapheresis in 9 donors and the effect of this procedure on the in vitro function of granulocytes in 3 donors. HES was eliminated more rapidly than has been previously reported for standard leukapheresis. Serum HES declined to one‐half of peak concentration between 1 and 2 days and to one‐tenth of peak in 23 days. No HES could be detected in serum 90 days after leukapheresis. The function of the harvested granulocytes was compared to that of granulocytes collected just prior to the procedure by measuring superoxide generation, ingestion and cell motility. There was no significant difference in the function of granulocytes harvested by low dose HES leukapheresis compared to those collected by venipuncture before the procedure.