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Immunoglobulin Class Heterogeneity of Platelet Alloantibodies
Author(s) -
Miller Karen,
Kickler Thomas S.,
Ness Paul M.,
Braine Hayden
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb03878.x
Subject(s) - platelet , antibody , immunology , antiserum , isoantibodies , medicine , immunoglobulin g , immunoglobulin m
. The immunoglobulin classes of platelet alloantibodies were studied using monospecific antisera in a radiolabeled technique. 14 of 28 consecutively studied multiply transfused oncology patients demonstrated platelet antibodies. These 14 patients were also refractory to random donor platelets. The immunoglobulin classes of these platelet antibodies were found to be: IgG alone 4, IgM alone 4, IgG and IgM 5, IgM plus IgA 1. The results in this study suggest that using monospecific antisera other than anti‐IgG alone, one can detect additional antibodies involved in the immune destruction of platelets.